APC 366 de-O-amido-C8-NH2 hydrochloride Smiles: CC1C=C(C(=O)NO)C(=C(C)C=1)N(CC1C=CC=CC=1)S(=O)(=O)C1=CC=C(C=C1)OCCNC(=O)C1=CC2=CC=CC=C2O1

Smiles: CC1C=C(C(=O)NO)C(=C(C)C=1)N(CC1C=CC=CC=1)S(=O)(=O)C1=CC=C(C=C1)OCCNC(=O)C1=CC2=CC=CC=C2O1

Anandamide is an endocannabinoid binding both CB1R and CB2R

InChiKey: SHXVYOLWYFZWKE-WOUKDFQISA-N

Tyrphostin AG 112 is an EGFR phosphorylation inhibitor

APC 366 de-O-amido-C8-NH2 hydrochloride Smiles: CC1C=C(C(=O)NO)C(=C(C)C=1)N(CC1C=CC=CC=1)S(=O)(=O)C1=CC=C(C=C1)OCCNC(=O)C1=CC2=CC=CC=C2O1APC 366 is a selective and competitive inhibitor of tryptase [1, 2, 3]. After about 4 h of incubation with human tryptase, APC 366 showed an inhibitory potential with a Ki value of 530 nM and an IC50 value of 1400 240 nM . Tryptase is a mast cell serine protease. It had been implicated in the allergic asthma pathophysiology . It seemed that actions of tryptase were dependent on an intact catalytic site. APC 366 inhibited DNA synthesis and the