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272(1):169-73
CC1N=CSC=1C1C=CC(CNC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](NC(=O)COCCOCCOCCOCCN)C(C)(C)C)=CC=1
limits activation of neutrophils and prevents acute lung injury induced by endotoxin in pigs
Currently Novartis is conducting clinical trials
BI-4464 Size:Contact [email protected] for quotation 272(1):169-73BI 4464 is a highly selective ATP competitive inhibitor of PTK2 FAK, with an IC50 of 17 nM. A PTK2 ligand for PROTAC. Product information CAS Number: 1227948 02 8 Molecular Weight: 555. 55 Formula: C28H28F3N5O4 Chemical Name: 3 methoxy N (1 methylpiperidin 4 yl) 4 ({4 [(3 oxo 2,3 dihydro 1H inden 4 yl)oxy] 5 (trifluoromethyl)pyrimidin 2 yl}amino)benzamide Smiles: COC1=CC(=CC=C1NC1N=C(OC2=CC=CC3CCC(=O)C=32)C(=CN=1)C(F)(F)F)C(=O)NC1CCN(C)CC1 InChiKey:
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