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3-benzothiazol-2-yl)-3-[9-methyl-2-(3-methylphenoxy)-4-oxo-4H-pyrido[1
InChiKey: VEPSYABRBFXYIB-PWXDFCLTSA-M
Chemical Name: [(1R)-1-[[(2S
Domingos M S Pereira
DMP 777 - CAS# 157341-41-8 oxacin(DU 6859A) 3-benzothiazol-2-yl)-3-[9-methyl-2-(3-methylphenoxy)-4-oxo-4H-pyrido[1DMP 777 also known as L 694458, is a potent and orally active Leukocyte elastase (HLE) inhibitor. Oral dosing with DMP 777 caused a rapid increase in serum gastrin levels and severe hypochlorhydria. DMP 777 inhibited aminopyrine accumulation into rabbit parietal cells stimulated with either histamine or forskolin. DMP 777 reversed a stimulated proton gradient in isolated parietal cell tubulovesicles. DMP 777 acts as a protonophore with specificity for
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