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On isolated rat ileum intestine
(+)-Curcumenol
12-trihydroxy-6
C4H4O4/c1-3-12-20(2)14-16-13-15-8-4-6-10-18(15)21-19-11-7-5-9-17(16)19
trans-AUCB opurvalanol A On isolated rat ileum intestineIC50: 0. 5 nM trans AUCB is a potent inhibitor of soluble epoxide hydrolase (sEH). Soluble epoxide hydrolase (sEH) can convert epoxides to their corresponding diols. Inhibitors of sEH have anti hypertensive, anti inflammatory, neuroprotective, and cardioprotective effects. In vitro: A previous study showed that the pretreatment with DAPT could substantially potentiate the growth inhibition caused by t AUCB in U251 and U87 cells. Moreover, the
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