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Ciacciarelli M
118(4):1052-61
reduces REM and slow wave sleep in vivo
modulates Th1 differentiation in CD4(+) T cells from patients with rheumatoid arthritis
SMI-4a - CAS# 438190-29-5 0256 Ciacciarelli MSMI 4a, CAS No. 438190 29 5, is a potent and selective Pim protein kinase inhibitor, which blocks the growth of precursor T cell lymphoblastic leukemia lymphoma. SMI 4a was found to induce phosphorylation of extracellular signal related kinase1 2 (ERK1 2), and the combination of SMI 4a and a mitogen activated protein kinase kinase 1 2 (MEK1 2) inhibitor was highly synergistic in killing pre T LBL cells. SMI 4a may be developed as a therapeutic