Vibunazole (BAY-N-7133) n-16 17-diol 12a-hexadecahydrochrysen-1-yl]propanoic acid

12a-hexadecahydrochrysen-1-yl]propanoic acid

2*3-1(4)2(5)6/h1-2

MMP-2 Inhibitor I inhibited the activity of matrix metalloproteinase (MMP)-2 with the Ki value of 1

5 μM) alone or incombination with cisplatin (CIS) dose-dependently reduces tumorigenic potential of ALDH1 positive cancer stem cells (CSCs)

Vibunazole (BAY-N-7133) n-16 17-diol 12a-hexadecahydrochrysen-1-yl]propanoic acidVibunazole is a new antifungal azole. Vibunazole is an antifungal azole. Low concentrations of all three drugs inhibit Coccidioides immitis, strain Silveira, in vitro with a descending order of activity ketoconazole>Vibunazole>BAY 1 9139. The untreated, infected mice lost weight initially and progressively, whereas treated mice gain weight after an initial loss with Vibunazole (all doses), BAY 1 9139 and ketoconazole at 2. 5 mg kg day. With both