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7-dioxobenzothiazoles as inhibitors of cyclin-dependent kinase 4 and cytotoxic agents
Ciraparantag
2017 May 9
CAS Number: 935666-88-9
GSK-923295 - CAS# 1088965-37-0 size:2mg solid 7-dioxobenzothiazoles as inhibitors of cyclin-dependentGSK 923295, CAS No. 1088965 37 0, also known as GSK 923295A, is a novel antimitotic inhibitor of centromere associated protein E (CENP E) with potential anticancer activity. GSK 923295A demonstrated significant antitumor activity against solid tumor models, inducing CRs in Ewing sarcoma, rhabdoid, and rhabdomyosarcoma xenografts. Clinical study showed that GSK 923295 had dose proportional pharmacokinetics and a low number of grade 3 or 4 adverse
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