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In R132H-IDH1 glioma xenografts (TS603)
Smiles: O=C(CCCCCN1C(=O)C=CC1=O)ON1C(=O)CCC1=O
Smiles: C/C(=N\NC(=S)N1CCC1)/C1=CC=CC=N1
488(7411):404-8
RVX-208 - BET Bromodomain Inhibitor. CAS# 1044870-39-4 60428 In R132H-IDH1 glioma xenografts (TS603)RVX 208, CAS No. 1044870 39 4, also known as Apabetalone, is a potent inhibitor of BET bromodomains. RVX 208 functions by removing atherosclerotic plaque via reverse cholesterol transport (RCT). RVX 208 increases the production of ApoA I in hepatocytes in vitro, and in vivo in monkeys and humans, which results in increased HDL C, but the molecular target was not previously reported. RVX 208 may be a promising new approach to the treatment of
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