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Smiles: C1C=NSC=1SSC1=CC=NS1
[Epub ahead of print] PubMed PMID: 30571144
is a BET bromodomain antagonist
InChiKey: BLMPQMFVWMYDKT-NZTKNTHTSA-N
Pyridostatin TFA salt - CAS# 1085412-37-8 167 Smiles: C1C=NSC=1SSC1=CC=NS1Pyridostatin, CAS No. 1085412 37 8, stabilizes G quadruplexes (G4s) in cells and elicits a DNA damage response by causing the formation of DNA double strand breaks (DSB). Pyridostatin promotes growth arrest in human cancer cells by inducing replication and transcription dependent DNA damage. Pyridostatin targets gene bodies containing clusters of sequences with a propensity for G quadruplex formation. As a result, pyridostatin modulated the expression
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