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PAI-039 is a small-molecule inhibitor of PAI-1 activity
Solvatochromism and linear solvation energy relationship of the kinase inhibitor SKF86002
This may eventually lead to the induction of apoptosis and may result in an inhibition of cell proliferation in cancer cells overexpressing SK2
2018 Jan 2
Capromorelin Tartrate 60107 PAI-039 is a small-molecule inhibitorCapromorelin Tartrate, also known as CP 424, 391, is a growth hormone secretagogue and ghrelin mimetic ( hGHS R1a K(i)=7 nM, rat pituicyte EC(50)=3 nM). Initial studies have shown the drug to directly raise insulin growth factor 1 (IGF 1) and growth hormone levels. Capromorelin showed enhanced intestinal absorption in rodent models and exhibited superior pharmacokinetic properties, including high bioavailabilities in two animal species [F(rat)=65%,
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