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20-triene-3
KW-8232 markedly decreases urinary calcium excreation in the neurectomized rats only at 30 mg/kg
DC260126 dose-dependently inhibits GPR40-mediated Ca2+ elevations stimulated by linoleic acid
5(4):355-7
Lysine-specific Demethylase Inhibitor (1C) orine hydrochloride 20-triene-3Lysine specific Demethylase Inhibitor (1C) is a lysine specific demethylase inhibitor. Lysine specific demethylase 1 (LSD1) is the first of several protein lysine demethylases identified. Through a FAD dependent oxidative reaction, LSD1 could specifically remove histone H3K4me2 to H3K4me1 or H3K4me0. When forming a complex with androgen receptor, LSD1 alters its substrates to H3K9me2. The LSD1 complex regulates a coordinated histone modification
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