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LY2835219 specifically inhibits CDK4 and 6
It also inhibits the proliferation of U87MG
and c-Myc)
and LOVO (WT)
E-7449 - CAS# 1140964-99-3 0290 LY2835219 specifically inhibits CDK4 andE 7449, also known as 2X 121, CAS No. 1140964 99 3, is an orally available small molecule inhibitor of the nuclear enzymes poly (ADP ribose) polymerase (PARP) 1 and 2, with potential antineoplastic activity. Upon administration, E 7449 selectively binds to PARP 1 and 2, thereby preventing the repair of damaged DNA via the base excision repair (BER) pathway. This agent enhances the accumulation of single and double strand DNA breaks and promotes
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