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Chemical Name: (S)-(4-fluorophenyl)(3-(3-(4-fluorophenyl)-1
its HCl salt has CAS#1448189-80-7
Saracatinib reduces the migration of human lung cancer A549 cells in a concentration-dependent manner (IC50 0
InChi: InChI=1S/C23H21ClN2O5/c1-30-22(28)14-9-7-13(8-10-14)21-20-16(15-5-3-4-6-17(15)25-20)11-18(23(29)31-2)26(21)19(27)12-24/h3-10
TH588 - MTH1 Inhibitor. CAS# 1609960-31-7 Catalog No.:M60211-10S Chemical Name: (S)-(4-fluorophenyl)(3-(3-(4-fluorophenyl)-1TH588, CAS No. 1609960 31 7, is a novel potent, selective and cell permeable inhibitor of the nudix hydrolase family MTH1 protein with an IC50 of ~5 nM. Protein co crystal structures demonstrate that TH588 binds in the active site of MTH1. It has excellent selectivity over other nudix family proteins and kinases present in the selectivity panel. The MTH1 protein sanitizes oxidized dNTP pools to prevent incorporation of damaged bases during DNA
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