GNF-7 - Ras Signaling Inhibitor. CAS# 839706-07-9 60427 (2003) Cancer Res

(2003) Cancer Res

OICR-9429 also disrupts the interaction of WDR5 with MLL1 and RbBP5 in cells with IC50 values below 1 µM

Abstract DDT02-01: GDC-0068: A novel

Stereospecific targeting of MTH1 by (S)-crizotinib as an anticancer strategy

GNF-7 - Ras Signaling Inhibitor. CAS# 839706-07-9 60427 (2003) Cancer ResGNF 7, CAS No. 839706 07 9, is a potent, selective and bioavailable Ras signaling inhibitor. It inhibits Ack1 and germinal center kinase (GCK). It can suppress proliferation, and induce cell cycle arrest and apoptosis in leukemia cells harboring NRAS mutations. In vivo GNF 7 showed good efficacy in a xenotransplantation model and activity against primary AML patient samples. Product information CAS Number: 839706 07 9 Molecular Weight: 547. 53