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KW-2449 mediates cytotoxicity thru inhibition of FLT3/ITD
but reduces open probability by > 90% with Ki=0
Chemical Name: 4-((4-Benzyl-5-(pyridin4yl)-4H-1
Kinetics experiments revealed that PF-03716556 has a competitive and reversible mode of action
Simvastatin - CAS# 79902-63-9 Size:Solid 2 mg KW-2449 mediates cytotoxicity thru inhibitionSimvastatin is a competitive inhibitor of HMG CoA reductase. This compound has been shown to modulate purified bovine pituitary 20 S proteasome via mild stimulation of chymotrypsin like activity and inhibition of peptidylglutamylpeptide hydrolyzing activity. Simvastatin is marketed under the trade name Zocor and is often prescribed in combination with ezetimibe to treat dyslipidemia. This drug combination is known commercially as Vytorin or Inegy.
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