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monovalent mimetic of second mitochondrial-derived activator of caspases (Smac/DIABLO) and inhibitor of IAPs (Inhibitor of Apoptosis Proteins) with potential antineoplastic activity
2ClH/c1-31(2)20-13-8-11-7-12-14(28)9-15(30-16(33)10-32-5-3-4-6-32)21(34)18(12)22(35)17(11)24(37)27(13
Maximum inhibition (70 to 80%) is achieved at 1 μg/mL (3 μM)
Chemical Name: 3-{[(1S
AG-370 Catalog No.:M22560-C monovalent mimetic of second mitochondrial-derivedIC50: 20 M for PDGF receptor kinase in human bone marrow fibroblasts AG 370 is a tyrphostin PDGFR inhibitor. Protein tyrosine kinase inhibitors are potential antiproliferative agents for diseases caused by the hyperactivity of protein tyrosine kinases. Tyrphostins are a class of antiproliferative agents selectively inhibiting protein tyrosine kinases of key growth factors including epidermal growth factor or platelet derived growth factor (PDGF) via
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