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GW-7647 (50 nM) enhances the initial phase of Ca2+-regulated exocytotic events stimulated by ACh in antral mucous cells
Single-dose pharmacokinetics and pharmacodynamics of RWJ 67657
Formula: C20H22ClNO4
2533/chimia
GSK-2606414 - CAS# 1337531-36-8 0435 GW-7647 (50 nM) enhances theGSK 2606414, CAS No. 1337531 36 8, is an orally available, potent, and selective PERK inhibitor. GSK 2606414 inhibits PERK activation in cells and inhibits the growth of a human tumor xenograft in mice. Protein kinase R (PKR) like endoplasmic reticulum kinase (PERK) is activated in response to a variety of endoplasmic reticulum stresses implicated in numerous disease states. Evidence that PERK is implicated in tumorigenesis and cancer cell survival
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