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It can inhibit oncogenic RAS signaling and suppress in vitro and in vivo proliferation of human pancreatic ductal adenocarcinoma cells that are dependent on oncogenic KRAS
Chemical Name: 4-{[(4-carboxybutyl)[2-(2-{[4-(2-phenylethyl)phenyl]methoxy}phenyl)ethyl]amino]methyl}benzoic acid
NU9056 was used at 24 µM final concentration in vitro and in cellular assays
CC(C)NCC(O)C1=CC=C(O)C(O)=C1
VU0364770 hydrochloride Size:Contact [email protected] for quotation It can inhibit oncogenic RASVU0364770 hydrochloride is a selective and potent positive allosteric modulator (PAM) of mGlu4. VU0346770 hydrochloride exhibits EC50s of 290 nM and 1. 1 M at rat mGlu4 and human mGlu4 receptor, respectively. VU0364770 hydrochloride exhibits antagonist activity at mGlu5 with a potency of 17. 9 M and PAM activity at mGlu6 with a potency of 6. 8 M. VU0364770 hydrochloride also possesses activity at MAO with Ki values of 8. 5 and 0. 72 M for human MAO A
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