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25)26)27-15(30)28-13(29)12-9(19)2-1-3-10(12)20/h1-6
39(2):319-25
Chemical Name: 11-(hydroxymethyl)-2-[3-(4-hydroxyphenyl)-2-{[1-(5-oxopyrrolidine-2-carbonyl)pyrrolidin-2-yl]formamido}propanamido]-3
Revlimid hydrochloride
TRV-120027 praglurant 25)26)27-15(30)28-13(29)12-9(19)2-1-3-10(12)20/h1-6TRV120027, a arrestin 1 biased agonist of the angiotensin II receptor type 1 (AT1R), engages arrestins while blocking G protein signaling. TRV120027 induces acute catecholamine secretion through cation channel subfamily C3 (TRPC3) coupling, promotes the formation of a macromolecular complex composed of AT1R arrestin 1TRPC3PLC at the plasma membrane. TRV120027 inhibits angiotensin IImediated vasoconstriction and increases cardiomyocyte contractility.
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