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5-dihydro-1H-imidazole-1-carbonyl)-2-oxopiperazin-1-yl)acetamido)ethyl)-3-(4-((2
InChi: InChI=1S/2C7H8N4O2
PubMed Central PMCID: PMC4844649
MYCi361 has moderate terminal elimination half-life of 44 and 20 h for intraperitoneal (i
Rhynchophylline C3-piperazine-N-Boc 5-dihydro-1H-imidazole-1-carbonyl)-2-oxopiperazin-1-yl)acetamido)ethyl)-3-(4-((2Rhyncholphylline, an alkaloid isolated from Uncaria, shows potent inhibition of lipopolysaccharide (LPS) induced NO production in rat primary microglial cells. IC50 value: Target: In vitro: Rhyncholphylline effectively suppresses release of proinflammatory cytokines in LPS activated microglial cells and the underling molecular mechanism for the inhibition of microglial activation; Attenuated LPS induced production of proinflammatory cytokines such as
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