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without affecting mu-agonist-mediated effects at doses >30-fold higher
A phase I dose-escalation
CAS Number: 52029-86-4
Mizukoshi Y
Naloxegol - CAS# 854601-70-0 Catalog No.:M6640-10S without affecting mu-agonist-mediated effects atNaloxegol, CAS No. 854601 70 0, also known as and NKTR 118 and AZ 13337019, is a peripherally selective opioid antagonist for the treatment of opioid induced constipation. It was approved in 2014 in adult patients with chronic, non cancer pain. Chemically, naloxegol is a pegylated (polyethylene glycol modified) derivative of naloxol. Specifically, the 5 hydroxyl group of naloxol is connected via an ether linkage to the free hydroxyl group of a
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