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and Aurora B with slightly lower potency
InChiKey: QNUKRWAIZMBVCU-WCIBSUBMSA-N
Delphinidin chloride
32 pM and 250 pM for Ramos
TL13-12 idine isethionate and Aurora B with slightlyTL13 12 is a potent and selective ALK PROTAC degrader and inhibits ALK activity with an IC50 value of 0. 69 nM. TL13 12 also prompts the degradation of additional kinases including Aurora A, FER, PTK2, and RPS6KA1 with IC50 values of 13. 5 nM, 5. 74 nM, 18. 4 nM, and 65 nM, respectively. TL13 12 is comprised of the conjugation of TAE684 (HY 10192) and the cereblon ligand of Pomalidomide (HY 10984). Product information CAS Number: 2229037 04 9
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