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to reduce anxiety-like behaviour and voluntary ethanol consumption in the iP (alcohol-preferring) rat
Formula: C19H21Br2N3O
InChi: InChI=1S/C29H26N4O2/c1-3-30-29(34)25-16-15-24(18-31-25)27-20(2)32-28-26(10-7-17-33(27)28)35-19-21-11-13-23(14-12-21)22-8-5-4-6-9-22/h4-18H
29)/t10-/m0/s1
M3814 (nedisertib) 8445 to reduce anxiety-like behaviour andNedisertib (M3814) is a potent and selective inhibitor of DNA dependent Protein Kinase (DNA PK), with an IC50 of <3 nM. Nedisertib (Compound 136) is a potent and selective inhibitor of DNA PK, with an IC50 of <3 nM for DNA PK and <0. 5 for cellular pDNA PK. In combination with IR, Nedisertib shows efficacy in all of the 6 mouse models of human cancer. In all models, a dose of 2 Gy administered daily for 1 week in combination with Nedisertib induces