8, 11, 14-Eicosatriynoic Acid 2iB Beta-glucuronidase-inhibitory activity and hepatoprotective effect

Beta-glucuronidase-inhibitory activity and hepatoprotective effect of Ganoderma lucidum

InChiKey: ZVBTZTQYHOXIBC-UHFFFAOYSA-N

5-1(3(7)8)2(6)4(9)10/h2*2-10

80 μM) inhibits the proliferation of SCC-9 and SAS cell lines in a dose- and time-dependent manner after treatment for 24 and 48 h

8, 11, 14-Eicosatriynoic Acid 2iB Beta-glucuronidase-inhibitory activity and hepatoprotective effect8,11,14 Eicosatriynoic Acid, as an inhibitor of prostaglandin, leukotriene biosynthesis, and arachidonic acid induced platelet aggregation, blocks human 12 lipoxygenase (12 LO), cyclooxygenase (COX), and 5 lipoxygenase (5 LO) with IC50 values of 0. 46 M, 14 M, and 25 M, respectively. Also, it inhibits the actions of slow reacting substance of anaphylaxis with an IC50 value of 10 M [1,2]. Lipoxygenases are found widely in fungi, plants, and animals in