CZC-25146 - CAS# 1191911-26-8 0088 as demonstrated by inhibition of

as demonstrated by inhibition of the ligand-dependent cell lines M-NFS-60 (IC50=380 nM) and M-07e (IC50=230 nM)

reduced brain inflammation

Chemical Name: 4-chloro-N-(2-((5-(trifluoromethyl)pyridin-2-yl)sulfonyl)ethyl)benzamide

Hoffmann M

CZC-25146 - CAS# 1191911-26-8 0088 as demonstrated by inhibition ofCZC 25146, CAS No. 1191911 26 8, is a potent and selective LRRK2 inhibitor. Leucine rich repeat kinase 2 (LRRK2) mutations are the most important cause of familial Parkinson's disease. CZC 25146 prevents mutant LRRK2 induced injury of cultured rodent and human neurons with mid nanomolar potency. Product information CAS Number: 1191911 26 8 Molecular Weight: 488. 54 Formula: C22H25FN6O4S Synonym: CZC25146 CZC 25146 CZC 25146 Chemical Name: N (2 ((5