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NC1=CN=CC(=N1)C1=CN2C=CN=C2C(NC2C=CC(=CC=2)N2CCN(CC2)C2COC2)=N1
which results in blockage of axonal transport and thus in axonal degeneration
CAS Number: 942142-51-0
Smiles: O=C1C(Br)=CC=C2[C@@H]3C[C@@H](CNC3)CN21
BMS-1166-N-piperidine-CO-N-piperazine 1193 NC1=CN=CC(=N1)C1=CN2C=CN=C2C(NC2C=CC(=CC=2)N2CCN(CC2)C2COC2)=N1BMS 1166 N piperidine CO N piperazine incorporates a ligand for PD 1 PD L1 immune checkpoint, and a PROTAC linker. BMS 1166 N piperidine CO N piperazine can be used in the synthesis of PROTAC PD 1 PD L1 degrader 1 (HY 131183). PROTAC PD 1 PD L1 degrader 1 inhibits PD 1 PD L1 interaction with an IC50 of 39. 2 nM. Product information CAS Number: 2447066 14 8 Molecular Weight: 707. 26 Formula: C41H43ClN4O5 Chemical Name: 3 [(4 chloro 5 {[3 (2,3 dihydro