AV-412 - CAS# 451493-31-5 Catalog No.:M10577-10 Chemical Name: N-[2-({[(2E)-3-(4-chlorophenyl)prop-2-en-1-yl](methyl)amino}methyl)phenyl]-4-methoxybenzene-1-sulfonamide hydrochloride

Chemical Name: N-[2-({[(2E)-3-(4-chlorophenyl)prop-2-en-1-yl](methyl)amino}methyl)phenyl]-4-methoxybenzene-1-sulfonamide hydrochloride

Smiles: Br

prevents prostate cancer growth and metastasis in a mouse xenograft model

Treatment with ESI-09 dramatically protects WT mice against R

AV-412 - CAS# 451493-31-5 Catalog No.:M10577-10 Chemical Name: N-[2-({[(2E)-3-(4-chlorophenyl)prop-2-en-1-yl](methyl)amino}methyl)phenyl]-4-methoxybenzene-1-sulfonamide hydrochlorideAV 412, also known as MP 412, is a second generation, orally bioavailable dual kinase inhibitor with potential antineoplastic activity. EGFR HER2 inhibitor AV 412 binds to and inhibits the epidermal growth factor receptor (EGFR) and the human epidermal growth factor receptor 2 (HER2), which may result in the inhibition of tumor growth and angiogenesis, and tumor regression in EGFR HER2 expressing tumors. This agent may be active against EGFR HER2