N106 - SERCA2a SUMOylation Activator. CAS# 862974-25-2 60019 prevents DNA-TLR9 interaction in vitro

prevents DNA-TLR9 interaction in vitro and modulates signaling in vivo

4-dihydro-1H-isoquinolin-2-yl]methanone

in a murine zosteriform spread model of cutaneous disease

CAS Number: 182431-12-5

N106 - SERCA2a SUMOylation Activator. CAS# 862974-25-2 60019 prevents DNA-TLR9 interaction in vitroN106, CAS No. 862974 25 2, is a potent SERCA2a SUMOylation activator, which increases SUMOylation of SERCA2a. Decreased activity and expression of the cardiac sarcoplasmic reticulum calcium ATPase (SERCA2a), a critical pump regulating calcium cycling in cardiomyocyte, are hallmarks of heart failure. The small ubiquitin like modifier type 1 (SUMO 1) is a regulator of SERCA2a and the gene transfer of SUMO 1 in rodents and large animal models of heart