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is a galectin-3 inhibitor potentially for the treatment of idiopathic pulmonary fibrosis (IPF)
13-heptaene-2-carboxamide
NPS-2143 (SB-262470A)
Sitagliptin has been shown to inhibit DPP-4 activity by > 90% within 1-2 h of administration
Aprepitant erin HCl is a galectin-3 inhibitor potentiallyAprepitant is a small molecule, high affinity substance P antagonist (SPA) with antiemetic activity. Crossing the blood brain barrier, aprepitant binds selectively to the human substance P neurokinin 1 receptor in the central nervous system (CNS), thereby inhibiting receptor binding of endogenous substance P and substance P induced emesis. This agent has little or no affinity for serotonin type 3 (5 HT3), dopamine, and corticosteroid receptors.
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