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2 macrophages activated with LPS (10 μg/mL) and INF (50 μg/mL)
It is the only benzodiazepine receptor antagonist on the market today
6)20-10-8-19(9-11-20)12-16(2)13-22-14-17(3)23-18(4)15-22
Chemical Name: N-(4-(trifluoromethoxy)phenyl)carbonohydrazonoyl dicyanide
Z-VDVAD-FMK 21843 2 macrophages activated with LPSJurkat T lymphocytes treated with an irreversible caspase 2 inhibitor, benzyloxycarbonyl Val Asp(OMe) Val Ala Asp(OMe) fluoromethyl ketone (Z VDVAD FMK), or stably transfected with pro caspase 2 antisense (Casp 2 AS) are refractory to cytochrome c release stimulated by etoposide1. When etoposide induced activation of pro caspase 2 is subverted by Z VDVAD FMK or stable transfection of pro caspase 2 antisense, cytochrome c release and other
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