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It acts by suppressing X-linked inhibitor of apoptosis protein (XIAP) and survivin levels
InChi: InChI=1S/C26H21F2N5O3/c1-33-15-16(14-30-33)21-11-18(7-10-29-21)36-23-13-19(27)22(12-20(23)28)32-25(35)26(8-9-26)24(34)31-17-5-3-2-4-6-17/h2-7
It induces apoptosis in MM cells resistant to conventional and bortezomib therapies
IC-87114 selectively inhibits PI3Kδ and not sensitive to PI3Kα
MK-4827 Hydrochloride l blocker It acts by suppressing X-linkedNiraparib, also know as MK 4827, is an inhibitor of poly (ADP ribose) polymerase (PARP) with potential antineoplastic activity. MK4827 inhibits PARP activity, enhancing the accumulation of DNA strand breaks and promoting genomic instability and apoptosis. The PARP family of proteins detect and repair single strand DNA breaks by the base excision repair (BER) pathway. Product information CAS Number: 1038915 64 8 Molecular Weight: 356. 85 Formula:
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