TMPA-AMPK Activator - CAS# 1258275-73-8 size:10mg solid selective and cell permeable G9a

selective and cell permeable G9a and GLP inhibitor

indicating that cycling populations of normal cells induce Chk1 pS345 following exposure to MK-8776 S-isomer as part of a futile cycle

At 5 μM it directly inhibits DUB activity of USP9x

Chemical Name: 7-(3

TMPA-AMPK Activator - CAS# 1258275-73-8 size:10mg solid selective and cell permeable G9aTMPA, CAS No. 1258275 73 8, is a novel small molecule that binds to orphan Nuclear Receptor Nur77 with high affinity (Kd = 1. 45 0. 35 M), and interferes with the Nur77 LKB1 interaction. TMPAs binding to Nur77 results in the release and shuttling of LKB1 to the cytoplasm to phosphorylate AMPK. TMPA treatment can effectively reduce blood glucose and alleviate insulin resistance in type II db db and high fat diet and streptozotocin induced diabetic mice