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PubMed PMID: 24698779
is a potent and orally active neurotrophic molecule discovered based upon efficacy in multiple cellular models of age-associated pathologies rather than exclusively amyloid metabolism
1 μM and IL4 driven proliferation with IC50=0
demonstrates robust in vivo efficacy in multiple models
MBX-2982 - CAS# 1037792-44-1 size:2mg solid PubMed PMID: 24698779MBX 2982, also known as SAR 260093, CAS No. 1037792 44 1, is a potential first in class treatment for type 2 diabetes that targets G protein coupled receptor 119 (GPR119), a receptor that interacts with bioactive lipids known to stimulate glucose dependent insulin secretion. Preclinical data indicate that MBX 2982 is a potent selective orally active GPR119 agonist that functions through a unique dual mechanism of action. First, it acts directly on the