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InChiKey: YWZUFJFIXFJKBD-XPWALMASSA-N
193(7):3278-87
CAS Number: 60-27-5
35)20-10-5-7-17(12-20)27(33)31(2)3)14-22-24(16)29-15-23(26(28)32)25(22)30-18-8-6-9-19(13-18)36-4/h5-15H
NB-360 Size:Contact [email protected] for quotation InChiKey: YWZUFJFIXFJKBD-XPWALMASSA-NNB 360 is a potent, brain penetrable, and orally bioavailable dual BACE1 BACE2 inhibitor (IC50: mouse and human BACE1=5 nM; BACE2=6 nM). NB 360 shows a superior pharmacological profile and robust reduction of amyloid and neuroinflammation in amyloid precursor protein(APP) transgenic mice. NB 360 can completely block the progression of A deposition in the brains of APP transgenic mice. NB 360 shows excellent selectivity over the related aspartyl
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