K-756 opam hydrochloride InChi: InChI=1S/C22H26O6/c1-23-17-7-5-13(9-19(17)25-3)21-15-11-28-22(16(15)12-27-21)14-6-8-18(24-2)20(10-14)26-4/h5-10

InChi: InChI=1S/C22H26O6/c1-23-17-7-5-13(9-19(17)25-3)21-15-11-28-22(16(15)12-27-21)14-6-8-18(24-2)20(10-14)26-4/h5-10

InChi: InChI=1S/C29H31F3N6O3/c1-36-26(21-9-7-19(16-33)8-10-21)24-25(35-36)27(40)38(18-34-24)17-28(41)11-13-37(14-12-28)23(39)15-22(29(30

It inhibits proliferation in a variety of cancer cell lines

Renaud A et al

K-756 opam hydrochloride InChi: InChI=1S/C22H26O6/c1-23-17-7-5-13(9-19(17)25-3)21-15-11-28-22(16(15)12-27-21)14-6-8-18(24-2)20(10-14)26-4/h5-10K 756 is a direct and selective tankyrase (TNKS) inhibitor, which inhibits the ADP ribosylation activity of TNKS1 and TNKS2 with IC50s of 31 and 36 nM, respectively. Product information CAS Number: 130017 40 2 Molecular Weight: 433. 50 Formula: C24H27N5O3 Chemical Name: 3 {[1 (6,7 dimethoxyquinazolin 4 yl)piperidin 4 yl]methyl} 1,2,3,4 tetrahydroquinazolin 2 one Smiles: COC1=CC2=NC=NC(=C2C=C1OC)N1CCC(CN2CC3C=CC=CC=3NC2=O)CC1 InChiKey: GWXCGEJJQFHPPA