Nepicastat Size:Solid 10 mg 6S)-6-[(1R)-1-hydroxyethyl]-7-oxo-3-[(2R)-oxolan-2-yl]-4-thia-1-azabicyclo[3

6S)-6-[(1R)-1-hydroxyethyl]-7-oxo-3-[(2R)-oxolan-2-yl]-4-thia-1-azabicyclo[3

InChi: InChI=1S/C34H57N2O4

3-weekly i

Smiles: CC1=C(C2C=CC(O)=CC=2)N(CC2C=CC(=CC=2)OCCN2CCCCCC2)C2=CC=C(O)C=C21

Nepicastat Size:Solid 10 mg 6S)-6-[(1R)-1-hydroxyethyl]-7-oxo-3-[(2R)-oxolan-2-yl]-4-thia-1-azabicyclo[3Nepicastat, also known as SYN117 and RS 25560 197, is an inhibitor of dopamine beta hydroxylase, an enzyme that catalyzes the conversion of dopamine to norepinephrine. It has been studied as a possible treatment for congestive heart failure, and appears to be well tolerated. As of 2012, clinical trials to assess nepicastat as a treatment for post traumatic stress disorder (PTSD) and cocaine dependence have been completed. In Phase 2 study treatment