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Small-molecule blocks malignant astrocyte proliferation and induces neuronal gene expression
especially the alpha-1 subunit
and 10 µM)
Chemical Name: ethyl 2-amino-6-chloro-4-(1-cyano-2-ethoxy-2-oxoethyl)-4H-chromene-3-carboxylate
BLU-9931 - CAS# 1538604-68-0 255 Small-molecule blocks malignant astrocyte proliferationBLU 9931, CAS No. 1538604 68 0, is a potent and irreversible small molecule inhibitor of FGFR4, as a targeted therapy to treat patients with HCC whose tumors have an activated FGFR4 signaling pathway. BLU 9931 is exquisitely selective for FGFR4 versus other FGFR family members and all other kinases. BLU 9931 shows remarkable antitumor activity in mice bearing an HCC tumor xenograft that overexpresses FGF19 due to amplification as well as a liver tumor