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PubMed PMID: 22736948
GS 5734-metabolite
O=C1C2=CC=CC=C2C(CC2C=CN=CC=2)(CC2C=CN=CC=2)C2=CC=CC=C21
but TSC1+/+ cells are resistant
Telotristat 845 PubMed PMID: 22736948Telotristat, also known as LP 778902, is the acid form of Telotristat ethyl, and the active metabolite of LX1606 (Telotristat etiprate), which is an orally bioavailable, small molecule, tryptophan hydroxylase (TPH) inhibitor and serotonin synthesis inhibitor with potential antiserotonergic activity. Blocking peripheral serotonin synthesis by telotristat reduces severity of both chemical and infection induced intestinal inflammation. Product