Asenapine 0289 is a tetracyclic antidepressant (TeCA)

is a tetracyclic antidepressant (TeCA) which acts as a noradrenergic and specific serotonergic antidepressant (NaSSA)

It has an IC50 of 0

Solubility: DMSO: 125 mg/mL (477

3-H)propan-2-yl]pyrimidin-5-yl]-3

Asenapine 0289 is a tetracyclic antidepressant (TeCA)Asenapine, also known as Org 5222 and HSDB 8061, shows high affinity (pKi) for numerous receptors, including the serotonin 5 HT1A (8. 6), 5 HT1B (8. 4), 5 HT2A (10. 2), 5 HT2B (9. 8), 5 HT2C (10. 5), 5 HT5A (8. 8), 5 HT6 (9. 5), and 5 HT7 (9. 9) receptors, the adrenergic 1 (8. 9), 2A (8. 9), 2B (9. 5), and 2C (8. 9) receptors, the dopamine D1 (8. 9), D2 (8. 9), D3 (9. 4), and D4 (9. 0) receptors, and the histamine H1 (9. 0) and H2 (8. 2) receptors.