OTS-964 hydrochloride - CAS# 1338545-07-5 054 Epub 2017 Nov 4

Name: OTS-964 hydrochloride - CAS# 1338545-07-5 054 Epub 2017 Nov 4
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SKU: 76817029921
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SKU: 76817029921

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Description

Epub 2017 Nov 4

Chemical Name: 5-methyl-10

780 and 1940 nM for ROCK1

1047645-82-8

OTS-964 hydrochloride - CAS# 1338545-07-5 054 Epub 2017 Nov 4OTS 964 hydrochloride, CAS No. 1338545 07 5, hydrochloride is a potent and selective TOPK inhibitor with potential anticancer activity. OTS964 inhibits TOPK kinase activity with high affinity and selectivity. Similar to the knockdown effect of TOPK small interfering RNAs (siRNAs), this inhibitor causes a cytokinesis defect and the subsequent apoptosis of cancer cells in vitro as well as in xenograft models of human lung cancer. Although administration

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