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A combinatorial strategy for treating KRAS-mutant lung cancer
Formula: C18H24N2OS
Novaluron is an insect growth regulator that is used against many field pests on corn
SAR131675 is the first highly specific VEGFR-3-TK inhibitor described to date
BGB-283 ide Rb3 A combinatorial strategy for treatingBGB 283 is a novel and potent Raf Kinase and EGFR inhibitor with IC50 values of 23 and 29 nM for recombinant BRafV600E and EGFR, respectively. BGB 283 potently inhibits BRafV600E activated ERK phosphorylation and cell proliferation. It demonstrates selective cytotoxicity and preferentially inhibits proliferation of cancer cells harboring BRafV600E and EGFR mutation amplification. In BRafV600E colorectal cancer cell lines, BGB 283 effectively inhibits
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