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It was shown to inhibit cell growth in cisplatin-resistant lung cancer cells
(2012) Biochem Biophys Res Commun
TUG-770 (Compound 22
It inhibits HDAC3 with IC50 of 289 nM
IRE-3 - IRE1a Modulator. CAS# 1414938-21-8 60319 It was shown to inhibitIRE 3, CAS No. 1414938 21 8, is a highly potent and selective small molecule modulator of IRE1. Under endoplasmic reticulum stress, unfolded protein accumulation leads to activation of the endoplasmic reticulum transmembrane kinase endoRNase (RNase) IRE1. IRE1 oligomerizes, autophosphorylates and initiates splicing of XBP1 mRNA, thus triggering the unfolded protein response (UPR). Interestingly, IRE 3 inhibits the XBP1 mRNA splicing through binding to
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