IU1 - Proteasome USP14 Inhibitor. CAS# 314245-33-5 size:10mg solid Formula: C19H18BrN3O

Formula: C19H18BrN3O

It was also used in an assay where primary bovine articular chondrocytes and cartilage explants were grown in the presence of TNF-a and oncostatin M to mimic cytokine-induced damage during OA pathogenesis

4-dihydroisoquinolin-2(1H)-yl)-2-hydroxypropyl)-6-(oxetan-3-ylamino)pyrimidine-4-carboxamide

TAME was used at 50-200 µM final concentration in various in vitro assays

IU1 - Proteasome USP14 Inhibitor. CAS# 314245-33-5 size:10mg solid Formula: C19H18BrN3OIU1, CAS No. 314245 33 5, is a cell permeable, reversible and selective inhibitor of human USP14 with an IC50 of 4. 7 M. It selectively stimulates ubiquitin dependent protein degradation in vitro at 34 M and in MEF cells at 50 M. At 75 M, IU1 reduces accumulation of oxidized proteins in HEK293 cells, alleviating cytotoxicity induced by oxidative stress. Usp14 inhibition accelerated the degradation of oxidized proteins and enhanced resistance to