BAY 41-8543 ME1 Smiles: CC1C=CC(=O)[C@H](C)C[C@H](CC=O)[C@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@@H]([C@H]2O)N(C)C)[C@@H](C)[C@H](O)CC(=O)O[C@H](CC)[C@@H](CO[C@@H]2O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]2OC)C=1

Smiles: CC1C=CC(=O)[C@H](C)C[C@H](CC=O)[C@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@@H]([C@H]2O)N(C)C)[C@@H](C)[C@H](O)CC(=O)O[C@H](CC)[C@@H](CO[C@@H]2O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]2OC)C=1

whereas the presence of a larger bromine atom at 6th position of the ring improves the inhibitory activity (5d

demonstrates biological activities against Aldose reductase (AR) and the formation of advanced glycation endproducts (AGEs)

Coghlan MJ

BAY 41-8543 ME1 Smiles: CC1C=CC(=O)[C@H](C)C[C@H](CC=O)[C@H](O[C@@H]2O[C@H](C)[C@@H](O[C@H]3C[C@@](C)(O)[C@@H](O)[C@H](C)O3)[C@@H]([C@H]2O)N(C)C)[C@@H](C)[C@H](O)CC(=O)O[C@H](CC)[C@@H](CO[C@@H]2O[C@H](C)[C@@H](O)[C@@H](OC)[C@H]2OC)C=1BAY 41 8543 is an orally active, nitric oxide (NO) independent stimulator of soluble guanylyl cyclase (sGC). BAY 41 8543 has vasodilator activity in the pulmonary and systemic vascular beds in the rat. BAY 41 8543 has antiplatelet effects and has the potential for cardiovascular diseases research. Product information CAS Number: 256498 66 5 Molecular Weight: 420. 44 Formula: C21H21FN8O Chemical Name: 2 {1 [(2 fluorophenyl)methyl] 1H pyrazolo[3,4