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384(1):166-9
low protein binding (88
Smiles: CC(CC(O)=O)CN
6-dimethoxy-3-methylcyclohexa-2
Compound 56 Catalog No.:M22023-C 384(1):166-9Compound 56, 4 [(3 Bromophenyl)amino] 6,7 diethoxyquinazoline, is a potent and specific inhibitor of the tyrosine kinase of the epidermal growth factor receptor (EGFR) showing an IC50 of 0. 006 nM. It competitively binds at the adenosine triphosphate (ATP) site of EGFR. Compound 56 is capable of inhibiting the phosphorylation of EGF dependent EGFR, suppressing the proliferation and clonogenicity of a wide panel of EGFR overexpressing human cancer
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