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is a Class I HDAC inhibitor (IC50 values are 0
Polyinosinic-polycytidylic acid (20 ng/mL
GBR12909 dihydrochloride
Formula: C19H23N3O5
Tazemetostat trihydrochloride - CAS# 1403255-00-4 NH-C8-NH2 hydrochloride is a Class I HDACTazemetostat trihydrochloride (EPZ 6438 trihydrochloride) is a potent, selective and orally available EZH2 inhibitor. Tazemetostat trihydrochloride inhibits the activity of human polycomb repressive complex 2 (PRC2) containing wild type EZH2 with a Ki of 2. 5 nM. Tazemetostat trihydrochloride inhibits EZH2 with IC50s of 11 and 16 nM in peptide assay and nucleosome assay, respectively. Tazemetostat trihydrochloride inhibits rat EZH2 with an IC50 of 4
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