MPI-0441138 Catalog No.:M22439-C Smiles: CN1N=CC2=CC(OC3=CC=C(C=C3F)NC(=O)C3=CC=C(C)N(C3=O)C3C=CC(F)=CC=3)=C(C=C12)C1C=NNC=1

Smiles: CN1N=CC2=CC(OC3=CC=C(C=C3F)NC(=O)C3=CC=C(C)N(C3=O)C3C=CC(F)=CC=3)=C(C=C12)C1C=NNC=1

Smiles: CN([C@@H](CC1C=CC(O)=CC=1)C(=O)N[C@H](CC(N)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCCNC(C)C)C(=O)N1CCC[C@H]1C(=O)N[C@H](C)C(N)=O)C(=O)[C@H](CO)NC(=O)[C@@H](CC1C=NC=CC=1)NC(=O)[C@@H](CC1C=CC(Cl)=CC=1)NC(=O)[C@@H](CC1C=C2C=CC=CC2=CC=1)NC(C)=O

SG3199 is a cytotoxic DNA minor groove interstrand crosslinking pyrrolobenzodiazepine (PDB) dimer

InChi: InChI=1S/C31H30N8O/c1-20-7-6-8-21(2)27(20)39-29(40)24-19-32-30(35-28(24)38-26-10-5-4-9-25(26)34-31(38)39)33-22-11-13-23(14-12-22)37-17-15-36(3)16-18-37/h4-14

MPI-0441138 Catalog No.:M22439-C Smiles: CN1N=CC2=CC(OC3=CC=C(C=C3F)NC(=O)C3=CC=C(C)N(C3=O)C3C=CC(F)=CC=3)=C(C=C12)C1C=NNC=1EC50: 2 nM for caspase activation MPI 0441138 is an inducer of apoptosis and growth inhibition. Apoptosis or programmed cell death is a process that organisms use to eliminate excessive cells and to control cell numbers. Caspases, a family of cysteine proteases, plays a critical role for the initiation as well as execution of apoptosis. In vitro: MPI 0441138 was identified as a highly active inducer of apoptosis and as a potent inhibitor of cell