Febuxostat 5132 SAR439859 shows promising antitumor activity

SAR439859 shows promising antitumor activity in breast cancer mice xenograft models

but also showing significant inhibition of other PDE subtypes

NODI and NOD2 are cytoplasmic receptors which play a key role in innate immune surveillance

PubMed PMID: 21677875

Febuxostat 5132 SAR439859 shows promising antitumor activityFebuxostat, also known as Uloric and TMX 67, is a xanthine oxidase inhibitor used to treathyperuricemia and chronic gout. Product information CAS Number: 144060 53 7 Molecular Weight: 316. 37 Formula: C16H16N2O3S Synonym: TEI 6720 TMX 67 Uloric FBX Chemical Name: 2 [3 cyano 4 (2 methylpropoxy)phenyl] 4 methyl 1,3 thiazole 5 carboxylic acid Smiles: CC1N=C(SC=1C(O)=O)C1=CC(C#N)=C(C=C1)OCC(C)C InChiKey: BQSJTQLCZDPROO UHFFFAOYSA N InChi: InChI=1S