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In cellular assays CP-690550 showed potent effects in the IL-2 blast proliferation assay (IC50 ~11 nM
and higher NAD+ baseline levels in MM cells than normal PBMCs confer (E)-Daporinad (FK866) sensitivity
The ubiquitin-activating enzyme E1 as a therapeutic target for the treatment of leukemia and multiple myeloma
Molecular Weight: 386
Carnosic Acid - CAS# 3650-09-7 60092 In cellular assays CP-690550 showedCarnosic Acid, CAS No. 3650 09 7, is a natural benzenediol abietane diterpene found in rosemary (Rosmarinus officinalis) and common sage (Salvia officinalis). Dried leaves of rosemary or sage contain 1. 5 to 2. 5% carnosic acid. Carnosic acid has medicinal properties, is a potent antioxidant and protects skin cells against UV A radiation (photoprotection). Studies in animals have also found a protection against carcinogens. Carnosic acid is used as a
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