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Formula: C18H11Cl2N3O3S3
Hedgehog signaling antagonist promotes regression of both liver fibrosis and hepatocellular carcinoma in a murine model of primary liver cancer
InChiKey: YCXDDPGRZKUGDG-UHFFFAOYSA-L
Functional up-regulation of P2X3 receptors in dorsal root ganglion in a rat model of bone cancer pain
(R)-5-Hydroxymethyl Tolterodine 2 inhibitor 1 Formula: C18H11Cl2N3O3S3Desfesoterodine, also known as PNU 200577, is a major pharmacologically active metabolite of tolterodine, a new muscarinic receptor antagonist intended for the treatment of an overactive bladder. In vitro, PNU 200577 produced a competitive and concentration dependent inhibition of carbachol induced contraction of guinea pig isolated urinary bladder strips (KB = 0. 84 nM; pA2 = 9. 14). In vivo, PNU 200577 was significantly more potent at inhibiting
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